Low-Level laser therapy enhances the number of ofosteocytes in calvaria bone defects of ovariectomized rats.
Douleurs chiens et chats
Scalize PH, de Sousa LG, GonçalvesLMN, et al. Low‐level laser therapy enhances the number ofosteocytes in calvaria bone defects of ovariectomized rats.Animal Model Exp Med. 2019;2:51–57.
The literature shows that estrogen plays an important role in thecontrol of osteocyte apoptosis and its maintenance. Estrogen deficiencymay compromise osteocyte viability,reducing bone capacity to respondadequately to applied forces,24 since mechanical behavior might be af fected by cell density.25 Therefore, an energy density of 30 J/cm2 ap plied for six and 12 sessions would promote an increase in osteocytedifferentiation, which in turn would also promote better bone function,allowing a better response of this tissue when forces are applied.The increase in the number of osteocytes following LLLT at anenergy density of 30 J/cm2 for six and 12 sessions might have pro duced an increase in secretion of sclerostin.
Sclerostin is a proteinintimately associated with the regulation of mineralization, callousossification, and bone remodeling, suggesting it plays a critical rolein bone consolidation after bone injury.26The results obtained in this study lead to the conclusion that LLLTstimulates bone neoformation, as shown by increased trabecular sur face area and the total number of osteocytes, especially when utilizinga laser energy density of 30 J/cm2 for six and 12 sessions. The datamight influence application of this therapy and bring clinical benefitswhen treatment designed to improve bone neoformation is needed.